The polyQ expansion modulates the configuration and phosphorylation of huntingtin
Tae‐Yang Jung, Baehyun Shin, Giorgio E. Tamò, Hyeongju Kim, Ravi Vijayvargia, Alexander Leitner, María J. Marcaida, Juan Astorga‐Wells, Roy Jung, Ruedi H. Aebersold, Matteo Dal Peraro, Hans Hebert, Ihn Sik Seong, Ji‐Joon Song
The paper examines how polyQ expansion affects HTT structure and phosphorylation, showing structural changes and altered phosphorylation patterns that influence HTT activity.
bioRxiv · Jul 31, 2019 · PreprintNeuroscience