Jiajun Chen

This study benchmarks deep learning methods for single-cell RNA sequencing integration, identifies limitations in existing metrics, and proposes improvements to better preserve biological signals.

scTFBridge infers gene regulatory networks from single-cell multi-omics data by integrating TF-motif binding knowledge, outperforming baselines in cis- and trans-regulation tasks.

This study identifies two DCD-related subtypes in glioma with distinct prognostic and immune characteristics using a risk score model based on DCD genes.