ImmunologybioRxivPreprint
REPTRA: Mapping Immune T Cell Receptor Activity from Full Sequences with a Debiased Contrastive Loss
John Abel, Brinda Vijaykumar, Neel Patel…·Daniel C. Pregibon
The paper introduces REPTRA, a contrastive learning model for TCR-epitope recognition using full TCR sequences and a debiased loss function, showing improved performance and highlighting the importance of CDR1 and CDR2.