Aminah Tasnim Ali

This study investigates the role of nuclear-encoded mitochondrial genes in ALS, finding enrichment in mitochondrial translation pathways and altered co-expression patterns, but no clear link between genetic risk and tissue expression changes.

The paper identifies FGF14 GAA repeat expansions in ALS patients, showing enrichment compared to controls and suggesting a broader pathogenic role in motor neuron disease.

The paper examines mitochondrial-nuclear gene relationships in human brain tissue, finding cell-type specific variations and disruptions in Alzheimer’s disease.

The paper quantifies variation in mitochondrial RNA modification levels across multiple tissues and identifies nuclear genetic variants associated with these modifications and disease phenotypes.