Youssef Idaghdour

Genomic Architecture, Differentiation, and Adaptation in Three Large Falcons

This study analyzes genomic divergence in three large falcon species, linking chromosomal rearrangements to patterns of recombination, diversity, and differentiation.

Federated single-cell QTL meta-analysis reveals novel disease mechanisms

The paper performs a federated cis-eQTL meta-analysis across single-cell datasets to identify cell-type-specific genetic effects and link them to disease mechanisms.

Integrative multi-omic analysis reveals oral microbiome-metabolome signatures of obesity

This study identifies oral microbiome and metabolome signatures associated with obesity through a multi-omics analysis of 192 matched samples from 628 Emirati adults.

Pathogenicity Reassessment and Novel Variant Discovery in Inherited Retinal Disease through Population-Scale Genomics in the United Arab Emirates

The paper reassesses pathogenicity of variants in inherited retinal diseases using population-scale genomics in the UAE, identifying clinically relevant variants and highlighting discrepancies between clinical and population-based classifications.

Nuclear actin-dependent Meg3 expression suppresses metabolic genes by affecting the chromatin architecture at sites of elevated H3K27 acetylation levels

This study shows that β-actin depletion increases Meg3 expression, which alters chromatin architecture and represses metabolic genes through promoter-enhancer interaction disruption.

Upregulation of steroidogenesis is associated with coma in human cerebral malaria

The paper identifies steroid biosynthesis as a key metabolic pathway associated with coma in cerebral malaria by analyzing metabolite differences between CM and CM-like patients.

Linked-Read Sequencing of Eight Falcons Reveals a Unique Genomic Architecture in Flux

The paper analyzes eight falcon genomes to investigate how chromosomal rearrangements affect genomic architecture and equilibrium.

Intergenerational epigenetic inheritance in reef-building corals

This study shows genome-wide CpG methylation inheritance in corals and links methylation variation to environmental factors like temperature and salinity.

Nuclear genetic regulation of human mitochondrial RNA modification

The paper quantifies variation in mitochondrial RNA modification levels across multiple tissues and identifies nuclear genetic variants associated with these modifications and disease phenotypes.

Genomic and Environmental Contributions to Chronic Diseases in Urban Populations

The paper investigates how environmental factors, particularly air pollution, interact with genetic variation to influence gene expression and chronic disease traits in an urban population.

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

This study shows that multi-site regulation of gene expression leads to biased eQTL fine mapping and highlights the need for joint multi-site analysis to improve accuracy.

Integrated Genomic Analysis of Mitochondrial RNA Processing in Human Cancers

The paper quantifies changes in mitochondrial RNA processing in cancers using genomic data from 1226 samples, finding altered methylation rates and associations with survival outcomes.

Recombination impacts damaging and disease mutation accumulation in human populations

The paper shows that recombination rate influences the distribution of deleterious variants across the human genome, with low recombination regions enriched for disease-associated mutations.