Guihong Wan

RECON selects regions of interest from H&E images and reconstructs molecular profiles across entire slides at single-cell resolution for both transcriptomics and proteomics.

The paper maps spatial patterns of tumor cell dedifferentiation and plasticity in melanoma by analyzing RNA and protein expression across 300 histological domains.

SpatialCells automates the analysis of spatially resolved multiplexed single-cell data to characterize tumor microenvironments, enabling efficient feature extraction and downstream machine learning applications.