Author

Aathira Sarath Chandran

St. Jude Children's Research HospitalORCID 0000-0003-1123-3953Unclaimed ORCID profile · follow to get notified of new preprints

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Annarita MiccioiD· 1 shared Anne ChalumeauiD· 1 shared Elena Retana· 1 shared Jonathan S. YeniD· 1 shared Marcello MarescaiD· 1 shared Maria Bou DamesiD· 1 shared Martin PeterkaiD· 1 shared Mégane BrussoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Annarita MiccioORCID

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1 paper

Recent·Most cited

BioengineeringMolecular Therapy — Nucleic AcidsPeer-reviewedJun 6, 2026

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to- activator motif switch in the HBG1/2 promoters

Anne Chalumeau, Panagiotis Antoniou, Maria Bou Dames…·Annarita Miccio

This paper demonstrates that replacing the BCL11A repressor binding site with a TAL1:GATA1 activator motif in HBG1/2 promoters enhances γ-globin reactivation and corrects sickle cell disease in hematopoietic stem/progenitor cells.

4 citationstop 1%

humanATAC-seq

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