Author

Elena Retana

Inserm

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Bioengineering· 1

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Aathira Sarath ChandraniD· 1 shared Annarita MiccioiD· 1 shared Anne ChalumeauiD· 1 shared Jonathan S. YeniD· 1 shared Marcello MarescaiD· 1 shared Maria Bou DamesiD· 1 shared Martin PeterkaiD· 1 shared Mégane BrussoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Aathira Sarath ChandranORCID

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1 paper

Recent·Most cited

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to- activator motif switch in the HBG1/2 promoters

Anne Chalumeau, Panagiotis Antoniou, Maria Bou Dames, Pierre Martinucci, Elena Retana, Pragya Gupta, Mike A. Firth, Muralidhar Reddivari, Aathira Sarath Chandran, Jonathan S. Yen, Martin Peterka, Marcello Maresca, Mégane Brusson, Annarita Miccio

This paper demonstrates that replacing the BCL11A repressor binding site with a TAL1:GATA1 activator motif in HBG1/2 promoters enhances γ-globin reactivation and corrects sickle cell disease in hematopoietic stem/progenitor cells.

Molecular Therapy — Nucleic Acids · Jun 6, 2026Peer-reviewedBioengineering