Author

Maria Bou Dames

InsermORCID 0009-0004-8325-8142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Annarita MiccioiD· 2 shared Anne ChalumeauiD· 2 shared Marcello MarescaiD· 2 shared Martin PeterkaiD· 2 shared Mégane BrussoniD· 2 shared Panagiotis AntoniouiD· 2 shared Aathira Sarath ChandraniD· 1 shared Carine GiovannangeliiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

Annarita MiccioORCID

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2 papers

Recent·Most cited

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to- activator motif switch in the HBG1/2 promoters

Anne Chalumeau, Panagiotis Antoniou, Maria Bou Dames, Pierre Martinucci, Elena Retana, Pragya Gupta, Mike A. Firth, Muralidhar Reddivari, Aathira Sarath Chandran, Jonathan S. Yen, Martin Peterka, Marcello Maresca, Mégane Brusson, Annarita Miccio

This paper demonstrates that replacing the BCL11A repressor binding site with a TAL1:GATA1 activator motif in HBG1/2 promoters enhances γ-globin reactivation and corrects sickle cell disease in hematopoietic stem/progenitor cells.

Molecular Therapy — Nucleic Acids · Jun 6, 2026Peer-reviewedBioengineering

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease

Anne Chalumeau, Maria Bou Dames, Letizia Fontana, Simone Amistadi, Panagiotis Antoniou, Priyanka Loganathan, Margaux Mombled, Guillaume Corre, Martin Peterka, Mario Amendola, Carine Giovannangeli, Marcello Maresca, Annarita Miccio, Mégane Brusson

This paper describes a prime editing strategy to modify γ-globin promoters in HSPCs to increase HbF expression for sickle cell disease treatment.

Blood · Aug 26, 2025Peer-reviewedMolecular Biology