Lindi M. Wahl

The paper analyzes how the distribution of fitness effects (DFE) changes during adaptation using simplified models and simulations, finding that DFE shifts left due to increasing deleterious mutations.

This study quantitatively predicts how environmental stress can promote mutator lineages through evolutionary rescue, showing their effectiveness depends on wildtype mutation rates and environmental change speed.

The paper shows non-hypermutator cancers adapt by reversing germline mutation bias, enabling access to driver mutations through altered mutation spectra.

The paper models how SARS-CoV-2 mutations are transmitted within-host, finding that mutations affecting innate immune evasion have higher transmission probabilities than those affecting humoral evasion.