Mariana Monteiro

This paper develops a metabolism-informed bioreactor model to transfer knowledge from fed-batch to continuous biomanufacturing by predicting intracellular fluxes and extracellular concentrations.

This paper introduces ObjFind-M, an inverse optimization framework that infers reaction-level metabolic objectives from fluxomic and metabolomic data in mammalian cells, finding mitochondrial ATP synthase as a central driver.