James Morrissey

This paper develops a multi-objective Bayesian Optimization framework for optimizing bioprocess conditions in CHO cell culture, achieving better performance than traditional methods with fewer experiments.

MCBO provides a standardized ontology for mammalian cell bioprocessing data to enable harmonization and querying of complex biomanufacturing datasets.

This paper introduces ObjFind-M, an inverse optimization framework that infers reaction-level metabolic objectives from fluxomic and metabolomic data in mammalian cells, finding mitochondrial ATP synthase as a central driver.

This study shows that nicotinamide reduces lactate accumulation and improves metabolic efficiency in Chinese hamster ovary cell cultures by reversing the Warburg effect.

The paper presents iCHO3K, a comprehensive metabolic model of Chinese Hamster cells, and uses it to analyze metabolic changes in lactate-free cells, identifying structural insights into metabolic rewiring.