Author

Michael G. Hahn

Bayer (Germany)ORCID 0000-0003-1205-9379Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Elisabeth P. CarpenteriD· 2 shared Karin E. J. RödströmiD· 2 shared Stephen J. TuckeriD· 2 shared Alice GardhamiD· 1 shared Amber Hogart BegtrupiD· 1 shared Andrew QuigleyiD· 1 shared Ashley C. W. PikeiD· 1 shared Aytuğ K. KiperiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Elisabeth P. CarpenterORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineNature GeneticsPeer-reviewedOct 1, 2022

Defective X-gating caused by de novo gain-of-function mutations in KCNK3 underlies a developmental disorder with sleep apnea

Janina Sörmann, Marcus Schewe, Peter Proks…·Stephen J. Tucker

The paper identifies de novo gain-of-function mutations in KCNK3 causing a developmental disorder with sleep apnea by disrupting X-gating of TASK-1 channels.

30 citations

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 19, 2019

A unique lower X-gate in TASK channels traps inhibitors within the vestibule

Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang…·Elisabeth P. Carpenter

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.

6 citations

experimental assayprotein structure prediction

𝕏 PostBluesky