Author

Ashley C. W. Pike

University of OxfordORCID 0000-0001-9661-2607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Organism:human· 2 Assay:cryo-EM· 1 Assay:protein structure· 1

Frequent Co-Authors

David Bryant SaueriD· 2 shared Gamma ChiiD· 2 shared Leela Shrestha· 2 shared Nicola A. Burgess-BrowniD· 2 shared Andrew QuigleyiD· 1 shared Anna LiiD· 1 shared Aytuğ K. KiperiD· 1 shared David BeesoniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

David Bryant SauerORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 3, 2026

Structural Basis for Inhibition of Human Anion Transporter SLC26A6/PAT-1

Gamma Chi, Tina Bohstedt, Roslin Adamson…·David B. Sauer

This study reports cryo-EM structures of human PAT-1 with inhibitors to elucidate their inhibition mechanisms and domain interactions.

DOI 10.64898/2026.11.01.757131

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 13, 2024

Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states

Anna Li, Ashley C. W. Pike, Richard G. Webster…·Yin Yao Dong

The paper presents structures of human adult muscle-type nicotinic receptors in resting and desensitised states and examines the effects of genetic variants on channel function.

DOI 10.1101/2024.12.13.624530

humanprotein structure

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 19, 2019

A unique lower X-gate in TASK channels traps inhibitors within the vestibule

Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang…·Elisabeth P. Carpenter

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.

6 citations

experimental assayprotein structure prediction

𝕏 PostBluesky