Timothy J. Sargeant

The paper measures autophagic flux in PBMCs of ASVD patients and finds it is elevated and inversely associated with adverse cardiovascular events.

SenLect is a genetic system to purify senescent cells by expressing a marker and antibiotic resistance under a senescence-activated promoter, enabling enrichment of senescent cells in culture.

The paper measures autophagic flux in 19 human blood cell sub-populations using flow cytometry, finding differences by cell type, sex, and age, with non-classical monocytes responding uniquely to amino acid withdrawal.

This study examines autophagic flux changes with age and diet in mice, revealing sexual dimorphisms across tissues.

The paper investigates transcriptional regulation of autophagy by identifying differentially expressed genes and their association with neurodegenerative pathways in response to autophagy induction.