Chen Mo

The paper examines how APOE4 modifies the effect of plasma LDL on white matter integrity in older adults, finding a significant moderation effect.

This paper introduces a new Mendelian Randomization method to estimate causal effects of multivariable brain imaging exposures and finds it outperforms existing methods in sensitivity, bias, and false discovery rate.

This paper introduces a novel ℓ0 graph norm shrinkage algorithm for genetic fine-mapping, demonstrating improved sensitivity and reduced false positives in identifying causal variants for nicotine dependence.

The paper evaluates vertical and horizontal pleiotropy pathways linking genetic variants, white matter integrity, and nicotine dependence using UK Biobank data.