Yezhi Pan

FM-GPT is a Bayesian fine mapping method that identifies causal genes in phenome-wide transcriptome-wide association studies, improving accuracy and reducing false positives.

This paper identifies systematic prediction bias in aging clocks and introduces a constrained optimization framework to improve calibration and downstream inference.

The paper evaluates test-retest reliability of brain imaging metrics across multiple sites and scanners, finding significant differences in reliability between scanner types.

The paper analyzes brain functional connectomes in 40,000 individuals to identify aging-related network changes, finding two motor-related subnetworks with age-related declines in functional connectivity.

The paper examines how APOE4 modifies the effect of plasma LDL on white matter integrity in older adults, finding a significant moderation effect.