Molecular BiologybioRxivPreprint
(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation
Alin Sebastian Porav, Alexandra Ptáková, Claudia C. Bauer…·Robin S. Bon
This study presents cryo-EM structures of TRPC5 bound to (-)-englerin A, revealing its binding site and mechanism of activation.
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