This paper develops and tests ideal efficacy photoswitch ligands for TRPC4/5 channels, enabling precise spatiotemporally-controlled modulation in live tissues.

13 citationstop 1%

experimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 9, 2025

(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation

Alin Sebastian Porav, Alexandra Ptáková, Claudia C. Bauer…·Robin S. Bon

This study presents cryo-EM structures of TRPC5 bound to (-)-englerin A, revealing its binding site and mechanism of activation.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyCommunications BiologyPeer-reviewedNov 23, 2020

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.

David J. Wright, Katie J. Simmons, Rachel M. Johnson…·Robin S. Bon

The paper reports the cryo-EM structure of human TRPC5 bound to the xanthine inhibitor Pico145, revealing its interaction with a conserved lipid binding site and elucidating the mechanism of TRPC1/4/5 modulation.

67 citations

humanexperimental assay

𝕏 PostBluesky