BiophysicsBiophysical JournalPeer-reviewed
One Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D Organization
Marcelo A. Carignano, Martin Kröger, Luay Matthew Almassalha…·Igal G. Szleifer
This paper introduces the SR-EV model to interpret chromatin organization as ensemble-level statistical patterns rather than fixed structures, showing how TADs and contact enrichments emerge from geometric rules and heterogeneity.
DOI 10.1016/j.bpj.2026.05.020