Igal G. Szleifer

This study shows that HP1 stabilizes chromatin packing domains by maintaining their structure and enabling efficient transcriptional responses to stress.

This paper introduces the SR-EV model to interpret chromatin organization as ensemble-level statistical patterns rather than fixed structures, showing how TADs and contact enrichments emerge from geometric rules and heterogeneity.

The paper proposes that introns, intergenic segments, and exons are positioned geometrically within chromatin domains to sustain transcriptional memory and reconcile epigenetic patterns and mutation non-randomness.

This study develops a physics-based model linking chromatin organization to chemoevasion, identifies TPR compounds that enhance chemotherapy efficacy in ovarian cancer.

This study theoretically examines how intranuclear factors like salt concentration and pH affect the charge state of nucleosome core particles, highlighting the role of magnesium ions and molecular details.

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.

The paper shows that RAD21 depletion reduces but does not eliminate chromatin packing domains in electron microscopy, suggesting non-cohesin mechanisms largely control 3D structure.

The paper introduces ChromSTEM, a method for high-resolution 3D imaging of chromatin structure, and finds that chromatin forms well-defined domains around 100 nm in radius with radially decreasing mass-density.

The paper introduces a nano-ChIA platform that combines electron tomography and superresolution imaging to study chromatin structure and dynamics at the single-nucleosome level in live cells.

The paper proposes a self-returning random walk model to explain interphase chromatin structure, reconciling high contact frequency and structural heterogeneity.