Author

Dritan Siliqi

National Research CouncilORCID 0000-0003-1415-8725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:simulation· 1

Frequent Co-Authors

Alessio BartocciiD· 1 shared Carmen AbateiD· 1 shared Costanza Paternoster· 1 shared Domenico AlbergaiD· 1 shared Gianluca LattanziiD· 1 shared Giuseppe Felice MangiatordiiD· 1 shared Vittoria NannaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alessio BartocciORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyJournal of Chemical Information and ModelingPeer-reviewedJun 1, 2026

✦ In-depth digest

MD simulations of Human Sigma1 Receptor Trimer Uncovers Cholesterol Dependent Stabilization and Ligand Specific Dynamics

Vittoria Nanna, Costanza Paternoster, Alessio Bartocci…·Giuseppe Felice Mangiatordi

Across 12 µs of all-atom simulations, cholesterol stabilizes the sigma-1 receptor trimer, while haloperidol, unlike (+)-pentazocine, engages β6-strand W136 to tighten interprotomer coupling.

2 citations

humanprotein structure

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