NeurosciencebioRxiv
Functional and Optogenetic Approaches to Discovering Stable Subtype-Specific Circuit Mechanisms in Depression
Logan Grosenick, Tracey C. Shi, Faith M. Gunning…·Conor M. Liston
The paper re-evaluates the stability of canonical correlations between functional connectivity and depressive symptoms using optimized statistical methods and demonstrates how optogenetic fMRI can test subtype-specific circuit mechanisms in depression.