Bruno Cuevas-Zuviría

This paper uses computational methods to study the structural disorder of Dsup and its interaction with the human nucleosome, revealing dynamic electrostatic shielding effects.

ChemOrigins is a community-curated database that organizes experimentally supported prebiotic reactions into a knowledge graph for research and education.

The paper evaluates macroscale and microscale metrics to distinguish biotic from abiotic chemical reaction networks and proposes an agnostic toolset for life detection.

The paper analyzes the evolutionary dynamics of RuBisCO, showing how the small subunit influenced the enzyme's conformational flexibility and response to atmospheric changes.

The paper reconstructs the structural evolution of nitrogenase enzymes over 3 billion years using phylogenetics, ancestral sequence reconstruction, crystallography, and deep learning.

The paper investigates heritability and autocatalysis in prebiotic chemical systems through serial dilution experiments and chemical reaction network analysis.

The paper constructs a multilayer graph of biochemical reactions for translation, polymer biosynthesis, and metabolism in E. coli, revealing distinct modular structures and multimodal distributions.