Author

Amanda K. Garcia

University of Wisconsin–MadisonORCID 0000-0002-1936-2568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Betül KaçariD· 2 shared Lance C. SeefeldtiD· 2 shared Bruno Cuevas-ZuviríaiD· 1 shared Derek F. HarrisiD· 1 shared Franka DetempleiD· 1 shared Hannah FeinsilberiD· 1 shared Holly R. RuckeriD· 1 shared Kaustubh AmritkariD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

Betül KaçarORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintNov 18, 2024

Structural evolution of nitrogenase enzymes over geologic time

Bruno Cuevas-Zuviría, Franka Detemple, Kaustubh Amritkar…·Betül Kaçar

The paper reconstructs the structural evolution of nitrogenase enzymes over 3 billion years using phylogenetics, ancestral sequence reconstruction, crystallography, and deep learning.

12 citations

protein structuredeep learning

𝕏 PostBluesky

Evolutionary BiologymBioPeer-reviewedJun 13, 2024

The Origins of ATP Dependence in Biological Nitrogen Fixation

Derek F. Harris, Holly R. Rucker, Amanda K. Garcia…·Lance C. Seefeldt

This study experimentally reconstructs an ancestral nitrogenase enzyme and shows it strictly requires ATP hydrolysis for N2 reduction, decoupling cofactor selection from environmental availability.

22 citations

experimental assay

𝕏 PostBluesky