Author

Derek E. Kelly

University of PennsylvaniaORCID 0000-0003-1555-595XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1

Frequent Co-Authors

Alessia RanciaroiD· 1 shared Christopher D. BrowniD· 1 shared Dawit Wolde MeskeliD· 1 shared Gregory R. GrantiD· 1 shared Gurja BelayiD· 1 shared Hongzhe LiiD· 1 shared Jia ChengiD· 1 shared Jibril B HirboiD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

Alessia RanciaroORCID

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2 papers

Recent·Most cited

GenomicsGenome biologyPeer-reviewedFeb 24, 2023

The Genetic and Evolutionary Basis of Gene Expression Variation in East Africans

Derek E. Kelly, Shweta Ramdas, Rong Ma…·Sarah A. Tishkoff

This study maps expression and splicing QTLs in East Africans and finds population-specific genetic variation related to immunity, metabolism, and pigmentation.

17 citations

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNucleic Acids ResearchPeer-reviewedSep 20, 2017

Accounting For Technical Noise In Single-Cell RNA Sequencing Analysis

Jia Cheng, Yu Hu, Derek E. Kelly…·Nancy Ruonan Zhang

The paper introduces TASC, a statistical framework to account for technical noise in scRNA-seq by modeling dropout rates and amplification bias, improving differential expression analysis.

90 citations

scRNA-seqstatistical model

𝕏 PostBluesky