Jia Cheng

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.

This study identifies hippocampal D2R neurons that regulate feeding behavior and encode food location memory through a LEC->Hippocampus->Septal circuit.

The paper introduces TASC, a statistical framework to account for technical noise in scRNA-seq by modeling dropout rates and amplification bias, improving differential expression analysis.