MicrobiologyClinical Microbiology and InfectionPeer-reviewed
Elucidating effects of single and multiple resistance mechanisms on bacterial response to meropenem by quantitative and systems pharmacology modeling and population genomics
Dominika T Fuhs, Sara Cortés-Lara, Jessica R. Tait…·Cornelia B. Landersdorfer
This study uses QSP modeling and population genomics to show that baseline resistance mechanisms in Pseudomonas aeruginosa affect bacterial killing and resistance emergence, and that fT>MIC cannot predict these outcomes.