Jessica R. Tait

This paper synthesizes and evaluates cationic lipid-terminated oligomers (CLOs) with potent and selective antibacterial activity against priority pathogens, showing low toxicity and tunable properties.

This study uses metabolomics to analyze how two CLOs disrupt MRSA membranes, revealing distinct metabolic changes that indicate membrane destabilization and lipid remodeling.

This study uses QSP modeling and population genomics to show that baseline resistance mechanisms in Pseudomonas aeruginosa affect bacterial killing and resistance emergence, and that fT>MIC cannot predict these outcomes.

This study uses metabolomics to reveal that C12-o-(BG-D)-10 disrupts bacterial membrane organization and multiple metabolic pathways, contributing to its antimicrobial activity against MRSA.