Cancer BiologybioRxivPreprint
Neuroendocrine-like/EMT dedifferentiation mediates resistance to EGFR inhibitors via the NRG1/HER3 axis
Alessandra Morselli, Chiara Miroglio, William Jayasekara Kothalawala…·Mattia Lauriola
The paper identifies NRG1/HER3 axis activation via NE-like/EMT dedifferentiation as a mechanism of EGFR inhibitor resistance in NSCLC and shows that combining EGFR inhibition with NRG1 neutralization can eradicate tumors.