Louis Coussement

This study evaluates the longitudinal behavior of organ-specific proteomic aging clocks over a decade, finding stability in age acceleration and links to subclinical risk factors and menopause in women.

The paper uses human pluripotent stem cells to study the epiblast development transition, revealing a transcriptional clock mechanism that governs timing and directionality through gene regulatory networks.

The paper develops MAGE, a tool for RNAseq-based genotyping and detection of allelic divergence in kidney tissues, identifying non-cis-eQTL ASE and aberrations in carcinoma.