Author

Rupert Handgretinger

University Children's Hospital TübingenORCID 0000-0003-1838-8990Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

AKM Ashiqul Haque· 1 shared Alexander Dewerth· 1 shared Aylin Neyazi· 1 shared Ayline KübleriD· 1 shared B Krämer· 1 shared Ben Felix Broesamle· 1 shared Boyu Zhao· 1 shared Brigitta LoretziD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

AKM Ashiqul Haque

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 27, 2026

Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation.

Ronja Larissa Schirrmann, Daniel Stowitschek, Malika Franziska Sutter…·Maya Caroline Andre

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

DOI 10.64898/2026.03.25.714180

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintOct 13, 2017

Modified hCFTR mRNA restores normal lung function in a mouse model of cystic fibrosis

AKM Ashiqul Haque, Alexander Dewerth, Justin S. Antony…·Michael Kormann

This study shows that modified hCFTR mRNA delivered as nanoparticles improves lung function in a mouse model of cystic fibrosis.

4 citations

mouseexperimental assay

𝕏 PostBluesky