Author

Ayline Kübler

University Medical Center of the Johannes Gutenberg University MainzORCID 0009-0007-9717-5569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Eliana StanganelloiD· 2 shared Elif DikeniD· 2 shared Mustafa DikeniD· 2 shared Özlem Akilli‐ÖztürkiD· 2 shared Uğur ŞahiniD· 2 shared Ahmad Al AlwashiD· 1 shared Alessandra GarganoiD· 1 shared Alexander MuikiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

Eliana StanganelloORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 3, 2026

Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature

Krutika Khinvasara, Elif Diken, Jennifer V. Gerbracht…·LAURA D. KOLB

This study identifies a CD8+ T cell molecular signature specific to small cell lung cancer, showing its prognostic value and potential for immunotherapy.

DOI 10.64898/2026.06.29.735200

humanscRNA-seq

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ImmunologybioRxivPreprintMay 11, 2026

Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune response

Ayline Kübler, Sophie-Christin Linkenbach, Fulvia Vascotto…·Uğur Şahin

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.

DOI 10.64898/2026.05.06.723126

mousebulk RNA-seq

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ImmunologybioRxivPreprintMar 27, 2026

Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation.

Ronja Larissa Schirrmann, Daniel Stowitschek, Malika Franziska Sutter…·Maya Caroline Andre

This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.

DOI 10.64898/2026.03.25.714180

humanbulk RNA-seq

𝕏 PostBluesky