Nicolas C. Rochette

The paper develops a quantitative model to understand PCR duplicate formation in sequencing datasets and shows library complexity and sequencing depth determine duplicate rates.

RADinitio simulates RADseq experiments to optimize protocol selection and identifies library preparation and sequencing as major sources of missing data.

Stacks 2 improves RADseq-based population genomics by using paired-end sequencing to assemble and genotype de novo datasets with high accuracy.