Prevalence and Actionability of MTAP Loss in Oncogene-Driven Lung Cancer
Takashi Sakai, Zofia Piotrowska, Charlotte I. Wang, Beow Yong Yeap, Rebecca Suk Heist, Jessica J. Lin, Lauren Highfield, Jennifer L. Petersen, Mandeep K. Banwait, Joyce H. Liang, Manisha Madhavan, Aaron N. Hata, Mari A. Mino-Kenudson, Ibiayi Dagogo‐Jack
The paper identifies MTAP loss in 18% of NSCLC specimens and shows PRMT5 inhibitors are effective in MTAP-deleted tumors, with enhanced activity when combined with TKIs.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology