Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.
Ludovica Marando, George Giotopoulos, Pedro Madrigal, Dhoyazan Azazi, Ryan J. Asby, María Eréndira Calleja-Cervantes, Muxin Gu, David Lara‐Astiaso, Nicola K. Wilson, Rebecca Hannah, Jaana Bagri, Emily F. Calderbank, Elisa Laurenti, Elsa Bernard, Sarah J. Horton, , Brian J.P. Huntly
This study shows that DNMT3A R882H mutant HSCs resist inflammatory stress through delayed p53 activation, leading to clonal expansion and increased AML risk.
bioRxiv · Jan 27, 2025 · PreprintMolecular Biology