Author

George Giotopoulos

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0003-1390-6592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Brian J.P. HuntlyiD· 3 shared Berthold GöttgensiD· 2 shared David Lara‐AstiasoiD· 2 shared Nicola K. WilsoniD· 2 shared Ryan J. AsbyiD· 2 shared A Lopez· 1 shared Ainhoa Goñi‐SalaverriiD· 1 shared Blaise Musabe· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

Brian J.P. HuntlyORCID

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3 papers

Recent·Most cited

Cancer BiologyOncogenePeer-reviewedSep 4, 2026

A Step-wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-relevant RTK-RAS Mutations

Marija Zarocsinceva, M. Saeed Qureshi, Nicola K. Wilson…·Berthold Göttgens

This study creates a mouse model of myeloid neoplasm with spontaneous RTK-RAS mutations, showing a premalignant phase and lineage restriction in tumors.

DOI 10.1038/s41388-026-03964-w

mousescRNA-seq

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Molecular BiologybioRxivPreprintJan 27, 2025

Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.

Ludovica Marando, George Giotopoulos, Pedro Madrigal…·Brian J.P. Huntly

This study shows that DNMT3A R882H mutant HSCs resist inflammatory stress through delayed p53 activation, leading to clonal expansion and increased AML risk.

DOI 10.1101/2025.01.27.635076

mousebulk RNA-seq

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GenomicsbioRxivPreprintAug 11, 2022

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

David Lara‐Astiaso, Ainhoa Goñi‐Salaverri, Julen Mendieta-Esteban…·Brian J.P. Huntly

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.

1 citation

mouseCRISPR screen

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