Molecular BiologybioRxivPreprint
Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.
Ludovica Marando, George Giotopoulos, Pedro Madrigal…·Brian J.P. Huntly
This study shows that DNMT3A R882H mutant HSCs resist inflammatory stress through delayed p53 activation, leading to clonal expansion and increased AML risk.
DOI 10.1101/2025.01.27.635076