In Silico Investigation of the Role of Local and Global Inflammation-Driven Feedback in Myelopoiesis and Clonal Cell Expansion
Yusuf Jamilu Umar, Symeon Savvopoulos, Charalampos Pitsalidis…·Haralampos Hatzikirou
This paper develops a mathematical model to study how local and global inflammation affects hematopoiesis and clonal expansion, identifying feedback thresholds that drive disease progression.