Michael Meyer‐Hermann

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

The paper uses an in silico model to show that multiple broadly neutralizing antibody lineages can co-exist and mature in germinal centres when primed by a single immunogen.

The paper uses in silico simulations to show that immunodominance in germinal centers is driven by the most immunogenic antigen, but increased vaccine valence may reduce this dominance.

BaM3 improves personalized tumor growth predictions by combining mechanistic modeling and machine learning, showing better performance in simulated and real patient data.

The paper develops an agent-based model to evaluate CTL killing mechanisms using 2-photon imaging data, finding that increased contact frequency with infected cells raises killing probability, independent of signal integration.

This study uses an agent-based model to show that TCR affinity modulation during immunological synapse formation depends on ligand density and F-actin dynamics, with centripetal transport and feedback mechanisms playing key roles.

This study simulates Alzheimer's disease progression using a mathematical model of the Amyloid cascade hypothesis, showing that brain geometry and neural activity influence amyloid plaque formation and neural atrophy.

This study develops a mathematical model showing that sleep disruption affects amyloid β fibrillization, suggesting that poor sleep hygiene may increase Alzheimer's disease risk by altering the balance between soluble and fibrillar amyloid β.

This paper introduces a 3D structural model for simulating germinal center responses to multi-epitope vaccines, showing that epitope cocktails enhance cross-reactive antibody development.

The paper develops a mathematical model of the immune response to Ebola infections to stratify patients and identify potential treatment strategies.

A theory-driven treatment using heat-killed S. aureus eradicates chronic infection, reduces MDSCs, and reverses T-cell dysfunction in mice.

The paper uses computer simulations to show that injecting antibodies against immunodominant epitopes can promote the generation of broadly neutralizing antibodies by focusing germinal centers on new epitopes.

The paper models cancer risk from young blood rejuvenation therapy and suggests treatment guidelines based on biological age and organ-specific cell turnover rates.

MoonFit provides a C++ interface for fitting ODE models, enabling biologists to perform simulations and optimizations without programming knowledge while allowing customization by programmers.

The paper quantifies CTLA4 internalization, recycling, and degradation rates using an in vitro-in silico approach and incorporates experimental data from human T cells.