Denoised MDS-UPDRS Part-III Scores Yield New Patterns of Progression Heterogeneity in Early Stage Parkinson's Disease
Jonathan Koss, Sule Tinaz, Hemant D. Tagare
This paper denoises MDS-UPDRS Part-III scores and performs high-dimensional analysis to show progression heterogeneity in Parkinson's disease is continuous and along two axes, not clustered subtypes.