GenomicsNature Structural & Molecular BiologyPeer-reviewed
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity
Alex Chialastri, Saumya Sarkar, Elizabeth E. Schauer…·Siddharth S. Dey
The paper introduces Dyad-seq to quantify 5mC and 5hmC at CpG dyads and combines it with transcriptome data (scDyad&T-seq) to show how DNMT1 fidelity depends on methylation density and histone modifications in mouse cells.
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