Author

Karen Vanhoorelbeke

KU LeuvenORCID 0000-0003-2288-8277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Mihaela DelceaiD· 1 shared Norman GeistiD· 1 shared Quintijn BonneziD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperMolecular Biology

Mihaela DelceaORCID

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1 paper

Recent·Most cited

Molecular BiologyJournal of Thrombosis and HaemostasisPeer-reviewedMay 22, 2026

Wrapping it Up: Structural Basis of ADAMTS13 Global Latency

Norman Geist, Quintijn Bonnez, Karen Vanhoorelbeke, Mihaela Delcea

This paper elucidates the structural basis of ADAMTS13 global latency by proposing a novel autoinhibition model where distal domains occlude substrate binding sites, explaining previously unexplained observations.

1 citation

humanprotein structure

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