Wheaton L. Schroeder

Enzyme-Constrained Metabolic Modeling of the Tripartite Synapse Links Astrocyte-Neuron Lactate Shuttle to Lipid Trafficking and Redox Homeostasis

This paper develops an enzyme-constrained metabolic model of the tripartite synapse to show that lactate shuttling between astrocytes and neurons arises from protein limitations and that FABP7 is critical for lipid-redox homeostasis.

The astrocyte Fabp7 gene regulates diurnal seizure threshold and activity-dependent gene expression in mice

This study shows that Fabp7 in astrocytes affects seizure thresholds and gene expression in mice, with effects dependent on time-of-day.

Dissecting the Metabolic Reprogramming of Maize Root under Nitrogen Limiting Stress Condition

This study develops a genome-scale metabolic model for maize root to analyze metabolic reprogramming under nitrogen stress, identifying key metabolites involved in biomass growth and stress tolerance.

A Computational Framework to Study the Primary Lifecycle Metabolism of Arabidopsis thaliana

This paper introduces a computational framework to model core carbon metabolism across the lifecycle of Arabidopsis thaliana, showing agreement with experimental data and enabling lifecycle metabolic studies.

KOPTIC: A novel approach for in silico prediction of enzyme kinetics and regulation

KOPTIC predicts enzyme kinetics and regulation using in silico data, achieving high correlation with input flux data and identifying regulatory interactions.

A Novel Optimization-Based Tool to Automate Infeasible Cycle-Free Gapfilling of Genome-Scale Metabolic Models

This paper introduces OptFill, a tool for automated gapfilling of genome-scale metabolic models that avoids thermodynamically infeasible cycles, applied to both fictional and published models.