Nicholas P. Tobin

The paper analyzes transcriptomic cancer hallmarks across cell cycle phases and breast cancer subtypes to identify drug targets and highlight the role of cell cycle phases in breast cancer biology.

The paper uses pathway activity estimated via singular value decomposition to predict survival time in breast cancer patients, finding it more prognostic than individual transcripts.

The paper analyzes DNA alterations across cell cycle activity levels in 9,515 cancer patients, finding that mutation frequencies vary with cell cycle activity and that cell cycle activity is a prognostic factor.