Zhong Chen

This study maps DNA methylation changes in 12 organs/tissues of spaceflight mice, showing tissue-specific and reversible epigenetic modifications linked to metabolic and immune dysregulation.

This study benchmarks five scCNV inference methods across multiple scRNA-seq platforms and mixed samples, finding variations in performance based on data characteristics and batch effects.

The paper provides comprehensive reference materials with genomic, epigenomic, transcriptomic, scRNA-seq, and proteomic characterizations of two cell lines for benchmarking and validation.

The paper presents whole-genome and whole-exome sequencing datasets from a multi-center, cross-platform study to benchmark NGS technologies and bioinformatics pipelines in cancer genomics.

The paper establishes reference samples with high-coverage whole-genome sequencing to create truth sets for somatic mutation and germline variant detection using NGS technologies.

This study evaluates reproducibility and accuracy of cancer mutation detection using whole-genome and whole-exome sequencing across multiple sequencing centers and bioinformatics pipelines.

This study benchmarks seven SARS-CoV-2 whole-genome sequencing protocols using patient samples, finding performance differences based on viral input and sequencing parameters.

This study shows spaceflight alters the DNA methylome and transcriptome in mouse retinas, slowing the epigenetic clock and affecting disease-related pathways.

This study compares somatic mutation detection accuracy using personalized genome assembly versus standard reference in cancer samples, showing improved results with personalized assemblies.