Author

Leslie Myint

Johns Hopkins UniversityORCID 0000-0003-2478-0331Unclaimed ORCID profile · follow to get notified of new preprints

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Leslie Myint1 paper

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dimitrios AvramopoulosiD· 2 shared Kasper D. HanseniD· 2 shared Loyal A. GoffiD· 2 shared Leandros BoukasiD· 1 shared Ruihua WangiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersGenetics

Dimitrios AvramopoulosORCID

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2 papers

Recent·Most cited

GeneticsAmerican Journal of Medical Genetics Part B Neuropsychiatric GeneticsPeer-reviewedSep 10, 2019

Testing the Regulatory Consequences of 1,049 Schizophrenia Associated Variants With a Massively Parallel Reporter Assay

Leslie Myint, Ruihua Wang, Leandros Boukas…·Dimitrios Avramopoulos

The paper tests 1,049 schizophrenia-associated variants using MPRA to identify functional effects on gene expression, finding no preference for risk alleles to increase or decrease expression.

46 citations

humanexperimental assay

𝕏 PostBluesky

BioinformaticsBMC GenomicsPeer-reviewedMar 12, 2019

Linear models enable powerful differential activity analysis in massively parallel reporter assays

Leslie Myint, Dimitrios Avramopoulos, Loyal A. Goff, Kasper D. Hansen

The paper introduces mpralm, a linear model for differential activity analysis in MPRA data, showing it outperforms existing methods and provides power analysis recommendations.

451 citationstop 1%

statistical modeldifferential expression

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