The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies
Anne‐Laure Mahul‐Mellier, Johannes Burtscher, Niran Maharjan, Laura Weerens, Marie Croisier, Fabien Kuttler, Marion Leleu, Graham William Knott, Hilal Ahmed Lashuel
This study develops a neuronal model of Lewy body formation and shows that the process of Lewy body maturation, not just fibrillization, drives neurodegeneration in synucleinopathies.
Proceedings of the National Academy of Sciences · Feb 19, 2020Peer-reviewedNeuroscience