Marion Leleu

This study investigates tandem repeat (TR) variation in stick insect genomes, finding TR enrichment in high-recombination regions and reduced loads in species with larger population sizes.

This paper develops a method to rapidly generate human 8-cell-like cells (ri8CLCs) using small molecules, enabling efficient modeling of early embryogenesis.

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

The paper develops a limb organoid model to study how signaling centers direct cell fate and spatial organization during limb development.

This paper investigates the role of Prdm1 in whisker development and its evolutionary loss, showing its regulatory impact on gene expression and neural organization in mice.

This study investigates whether CAG/CTG repeat expansion alters chromatin folding using 4C sequencing and finds that chromatin contacts remain stable despite repeat expansion.

This study develops a neuronal model of Lewy body formation and shows that the process of Lewy body maturation, not just fibrillization, drives neurodegeneration in synucleinopathies.

This study uses single-cell mRNA profiling to reveal the transcriptional logic of cell fate specification and axon guidance in early retinal neurons, identifying new molecular markers and regulatory sequences.

The paper analyzes single-cell transcriptomes of developing mammalian limb buds to show that Hoxd genes are expressed in specific combinations linked to cell types and follow a pseudotime trajectory during digit development.

The paper investigates how genomic rearrangements affect TAD structures at the HoxD locus by analyzing long-range chromatin interactions and boundary selection mechanisms.