This study identifies genetic associations between lysosomal genes and Parkinson's disease risk across diverse populations using GWAS and whole genome sequencing data.

npj Parkinson s Disease · Dec 2, 2025Peer-reviewedGenetic & Genomic Medicine

The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance

Lara Mariah Lange, Zih‐Hua Fang, Mary B. Makarious, Nicole Kuznetsov, Kajsa Atterling Brolin, Shannon L. Ballard, Soraya Bardien, Maria Leila M. Doquenia, Peter Heutink, Henry Houlden, Hirotaka Iwaki, Simona Jasaityte, Lietsel Jones, Johanna Junker, Rauan B. Kaiyrzhanov, , the Global Parkinson’s Genetic Program (GP2)

This paper analyzes genetic variation in Parkinson's disease across multiple ancestries, revealing ancestry-specific patterns and highlighting the importance of diverse populations in genetic research.

medRxiv · Jul 8, 2025 · PreprintGenetic & Genomic Medicine

Insights into Ancestral Diversity in Parkinsons Disease Risk: A Comparative Assessment of Polygenic Risk Scores

Paula Saffie Awad, Spencer M. Grant, Mary B. Makarious, Inas Elsayed, Arinola O. Sanyaolu, Peter Wild Crea, Artur Francisco Schumacher Schuh, Kristin S. Levine, Dan Vitale, Mathew J. Koretsky, Jeffrey Kim, Thiago Peixoto Leal, María Teresa Periñán, Sumit Dey, Alastair John Noyce, , Edward A. Fon

This study compares polygenic risk scores for Parkinson's disease across seven ancestries, finding varying predictive accuracy and highlighting the need for ancestry-specific models.

npj Parkinson s Disease · Jul 3, 2025Peer-reviewedGenetic & Genomic Medicine

Multi-ancestry genome-wide meta-analysis in Parkinson's disease

Jonggeol Jeffrey Kim, Dan Vitale, Diego Véliz Otani, Michelle Mulan Lian, Karl Heilbron, Stella W. Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, Emily Bullis, Paul Cannon, Daniella Coker, Gabriel Cuéllar-Partida, , Piu Chan

This paper conducts a multi-ancestry genome-wide meta-analysis of Parkinson's disease, identifying 78 independent loci and 23 genes associated with PD risk.

Nature Genetics · Dec 28, 2023Peer-reviewedGenetic & Genomic Medicine

Global Parkinson's Genetics Program (GP2) Complex Network Protocol: Defining the causes of sporadic Parkinson's disease

Clodagh Towns, Madeleine Richer, Simona Jasaityte, Eleanor J. Stafford, Julie Joubert, Tarek Antar, Alejandro Martínez-Carrasco, Mary B. Makarious, Bradford H. Casey, Dan Vitale, Kristin S. Levine, Hampton L. Leonard, Caroline B. Pantazis, Laurel A. Screven, Dena G. Hernandez, , Andrea Quattrone

The paper outlines the protocol for integrating genetic and clinical data from a global cohort of over 150,000 participants to study the genetic causes of sporadic Parkinson's disease.

npj Parkinson s Disease · Sep 12, 2023Peer-reviewedGenetic & Genomic Medicine